24 Publications in Peer Reviewed Journals / 28 Abstracts in National and International Meetings

  1. Singaram, C., Thyagarajan, D.K. and Solomon, S. incidence of HBsAg positivity in rheumatoid arthritis. Indian Council of Medical Research 27:96-111, 1982.
  2. Singaram, C., Vijayabasker, K. and Kameswaren, L. Serum salicylate levels in rheumatoid arthritis. Indian Council of Medical Research 28:238-244, 1983.
  3. Singaram, C. and Natarajan, A. Know Your Stesthoscope. Laipauk Medical Journal 1:25-27, 1983.
  4. Singaram, C., Sengupta, A., Spechler, S.J. and Goya, R.K. Mucosal peptidergic innervations of the opossum esophagus and anal canal: a comparison with snout skin. J Auton Ner Syst 29:231-240, 1990.
  5. Singaram, C., Sengupta, A., Sugarbaker, D.J. and Goyal, R.K. Peptidergic innervation of the human esophageal smooth muscle. Gastroenterology 101:1256-1263, 1991.
  6. Singaram, C., Sengupta, A., Stevens, C., Spechler, S.J. and Goyal, R.K. Localization of calcitonin gene-related peptide in human esophageal langerhans cells. Gastroenterology 100:560-563, 1991.
  7. See, N., Singaram, C., Epstein, M.L., Dahl, J.L. and Rigs, P. Reinnervation of viii of rat jejunum following severe mucosa damage. Dig Dis Sci 37:3:438-448, 1992.
  8. Stevens, C., Singaram, C., Lipman, M.L., Zanker, B., Muggia, A., Antonioli, D., Peppercorn, M.A. and Strom, T.B. Tumor necrosis factor-alpha, interleukin-Ibeta, and interleukin-6 expression in inflammatory bowel disease. Dig Dis Sci 37(0:818-826) 1992.
  9. Alderman, S., Kailas, S., Goldfarb, S., Singaram, C. and Malone, D.G. Cholestatic hepatitis after ingestion of chaparral leaf: Confirmation by endoscopic retrograde cholangiopancreatograpghy and liver biopsy. J Cline Gastroenterol 19:242-247, 1993.
  10. Mosley, R.G., Reichelderfer, J., Sengupta, A. and Singaram, C. Innervation of esophageal ecstatic submmacul blood vessel in achalasia and a comparison with normals. The American Journal of Gastroenterology 89:10:1874-1879, 1994.
  11. Singaram, C., Sengupta, A., Sweet, M.A., Sugarbaker, D.J. and Goyal, R.K. Nitrinergic and peptidergic innervations of human esophagus. Gut 35:12:1690-1696, 1994.
  12. Gaumnitz, E.A., Sweet, M.A., Sengupta, A. and Singaram, C. Nitrinergic and peptidergic innervations and their inter-relationships to human colon. Neuropeptides 29:1-9, 1995.
  13. Gaumnitz, EA, Russ, P., Osinski, M.A., Sweet, M.A. and Singaram, C. Electrophysiological and pharmacological responses of chronically denervated lower esophageal sphincter of the opossum. Gastroenterology 109:789-799, 1995.
  14. Jouet, P., Singaram, C., Sarna, S., Ryan, R.P., Hillard, CJ., Telford, G.L., Fink, J. and Henderson, J.D. Immunocytes and abnormal Gastrointestinal motor activity during ileitis in dogs. Am J Physiology 269:913-924, 1995.
  15. Lin, T., Matsuzaki, G., YH., Kenai, H., Omoto, K., Unesue, M., Singaram, C. and Nomoto, K. Thymus ontogeny and e development of TCR A/B CD4+CD8+ A/A and TCR A/B CD4-CD8+ A/A IEL: Further evidence suggesting a thymus origin for most TCR A/B IEL. J Immunol 155:1995.
  16. Lin, T., Matsuzaki, G., Kenai, H., Singaram, C. and Nomoto, K. Extrathymic and thymic origin of murine IEL. Are most IRi._in euthymic mice derived from the thymus? Immunology and Cell Biology 73:469-473, 1995.
  17. Lin, T., Matsuzaki, G., Umesue, M., Omoto, K., Yoshida, H., Harada, M., Singaram, C., Hiromatsu, K. and Nomoto, K. Development of TCR- G/D CD4-CD8+ A/A but not TCR- A/B CD4-CD8+ A/A i-IEL is resistant to cyclosporine Al. J Immunology 155:4224-4230, 1995.
  18. Lin, T., Singaram, C., Harms, B., Gaumnitz, E.A. and Singaram, C. A severe case of diversion colitis; 10 1995.
  19. Singaram, C., Ashraf, W., Torrey, C., Sengupta, A., Pfeiffer, R. and Quigley, E.M.M. Dopaminergic defect of enteric nervous system in Parkinson’s disease patients with chronic constipation. Lancet 346:861-864, 1995.
  20. Singaram, C., Torbey, C. and Jacoby, R. Delayed postpolypectomy bleeding. The American Journal of Gastroenterology 90:1:146-147, 1995.
  21. Singaram, C., Sweet, M.A., Gauinnitz, E.A., Cameron, A.J. and Camilleri, M. Peptidergic and nitrinergic denervation in congenital esophageal stenosis. Gastroenterology 109:275-281, 1995.
  22. Moore, B.G., Singaram, C., Eckhoff, D.E., Gaumnitz, E.A. and Starling, J.R. Immunohistochemical evaluation of an ultra-short Hirschsprung’s disease and literature review. Diseases of the Colon and Rectunt 73:321-328, 1996.
  23. Singaram, C., Sweet, M.A., Bass, P. and Snipes, R.L. An opossum model of achalasia using distal esophageal myenteric denervation. Neurogastroenterology and Motility. 9:238-246, 1996.
  24. Sweet, M., Gaumnitz, E.A., Weindruck, R., Singaram, C. NPY-and PYY-containing enterochromaffin cells incrase with aging in rats. Neuropeptides. 67:342-349, 1996.
  25. Singaram, C. Neuropathology of the enteric nervous system. Reviews in Neurology 1997. 84:231-243.
  26. Singaram, C. and Sengupta, A. Enteric dopaminergic defect in Parkinson’s disease. Biomedicine and Phannacotherapy 87:54-55, 1997.
  27. Singaram, C. Dopaminergic neurons are lost, as in the brain, in colons of constipated patients with Parkinson’s diceace Parldnson/Alzheimer Digest 3:11-13, 1997.
  28. Singaram, C et al., Treatment strategies based on the serogenetics in Patients with Crohn’s Disease; Gastroenterology & Hepatology: May of 2011

Reviews & Book Chapters

  1. Bass, P., Singaram, C. Proprieta’ catariche dei disaccaridi. In: Hepatic Encephalopathy, edited by Conn, H., Bircher, J. and Orlandi, F. Medi Ed Press, 1992, p. 158-169.
  2. Singaram, C., Sengupta, A. Histopathology of the enteric nervous system in the small intestine. Editor: Quiggley, E.M.M. Boston: Blackwell Scientific, 1996.
  3. Singaram, C. A team approach to ethical management of an elderly patient with dysphagia. In: Prospective on dysphagia treatment in management stratagies, Editor: Sonies, B. Gaithersburg: Aspen Inc., 1996, p. 87-91.
  4. Singaram, C. and Sengupta, A. Histopathology of the enteric neuropathies. In: Gastrointestinal motility in clinical practice, edited by Camilleri, M. Boston: W.B. Saunders, 1996, p. 265-277.
  5. Singaram, C: Market Positioning in Bio-Technology in India, Elsiver Publication, 2009.
  6. Singaram, C: Impact of Bio-Technology in Indian Health Care System; Hindu Newspaper Review January 2010.


(*Abstract competitively selected for presentation either at a National or International Meeting.)

  1. *Singaram, C., Sengupta, A., Mamish, D., Spechler, S.J. and Goyal, R.K. Peptidergic innervations of the epithelium of the opossum esophagus and anal canal. Gastroenterology 96:A474, 1989.
  2. *Singaram, C., Sengupta, A., Sugarbaker, D.J. and Goyal, R.K. Peptidergic innervating of human esophagus. Gastroenterology 98:A392, 1990.
  3. *Singaram, C., Saigupta, A., Stevens, C., Spechler, S.J. and Goyal, R.K. CGRP-immunoreactive cells in human esoaphageal mucosa; Identification as Langerhans cells. Gastroenterology 98:A474, 1990.
  4. Singaram, C., Sengupta, A., May , R. and Goyal, R.K. NPY-Immunoreactive cells in human colonic mucosa. Gastroenterology 98:A523, 1990.
  5. *Stevens, C., Walz, G., Zanker, B., Singaram, C., Lipman, M. and Strom, T.B. IL-6, Interlukin-1 BETA (IL-lb) and TNFa expression in inflammatory bowel disease (133D). Gastroenterology 98:A475, 1990.
  6. *Singaram, C., Sengupta, A., Winter, H., Kozakewich, H. and Goyal, R.K. Immunocytochemical localization of neuropeptides in neuronal dysplasis. Gastroenterology 100:A495, 1991.
  7. Singaram, C., Osinski, M.A., White, J.C., Dahl, J.L. and Bass, P. Intraluminal trinitrobenzene sulfonic acid (TNBS) stimulates the production of activated dendritic cells as well as neutrophils and other immunocytes in the rat colon. Gastroenterology 102:A697, 1992.
  8. Singaram, C., Epstein, M., Dahl, J.L., Reichelderfer, M. and Bass, P. A novel method for producing total denervation in segments of rat colon and jejunum. Gastroenterology 102:A514, 1992.
  9. *Singaram, C., Dahl, J., Epstein, M., Reichelderfer, M. and Bass, P. Submucous neurons are necessary for regeneration of rat jejuna muscle layers. Gastroenterology 103:4:1387, 1992.
  10. *Gaumnitz, E.A., Sweet, M.A., Sengupta, A. and Singaram, C. The nitrinergic system in human colon and its relationship with the peptidergic enteric nervous system. Gastroenterology 104:A511, 1993.
  11. *Johnson, N.R., Sweet, M.A., Bass, P. and Singaram, C. Experimental Studies on the Origin and Coexistence of Nitrinergic and Peptidergic Systems in Rat Jejunum. Gastroenterology 104:A1044, 1993.
  12. *Sengupta, A., Singaram, C., Kushak, R., Goyal, R.K. and Winter, H. Nitrinergic and VIP-ergic Neural Interconnections in 17-week Old Human Fetal Gut. Gastroenterology 104:A580, 1993.
  13. *Singaram, C., Saigupta, A., Sweet, M.A., Reichelderfer, M. and Goyal, R.K. Selective loss of nitrinergic and CGRP innervations in esphagal azhalasia. Journal of Gastrointestinal Motility 5:218, 1993.
  14. Singaram, C., Epstein, M.L., Dahl, J.L. and Bass, P. A novel method for total anganglionic segments of rat jejunum and colon. Gastroenterology 100:A867, 1993.
  15. *Singaram, C., Sengupta, A., Sweet, M.A., Winter, H.S., Sugarbaker, D.J. and Goyal, R.K. Nitrinergic and Peptidergic Innervation of Human Esophagus. Gastroenterology 104:A583, 1993.
  16. *Singaram, C., Sweet, M.A., Reichelderfer, M. and Robbins, J. Lack of Calcitonin Gene-Related Pepetide (CGRP) Intraepithelial Fibers (IEF) is Characteristic of Esophageal Dysmotility in the Elderly. Gastroenterology 104:A647, 1993.
  17. *Singaram, C., Sweet, M.A., Winter, H.S., Robbins, J., Goyal, R.K. and Sengupta, A. Nitrinergic and peptidergic innervations of the human esophageal mucosa. Journal of Gastrointestinal Motility 5:218, 1993.
  18. *Snipes, R.L., Sweet, M.A., Reichelderfer, M., Bass, P. and Singaram, C. An Animal Model for Esophageal Achalasia Using Myenteric Denervation. Gastroenterology 104:A195, 1993.
  19. Sweet, M.A., Bass, P. and Singaram, C. Morphological evaluation of nitrinergic system in rat g.i. tract: A correlation with peptidergic nervous system. Gastroenterology 104:A857, 1993.
  20. *Singaram, C., Sweet, M.A., Belcaster, G.M., Hefle, S.L., Kalloo, A.N. and Pasricha, J. A novel autoantibody exists in patients with esophageal achalasia. Gastroenterology 106:A566, 1994.
  21. *Singaram, C., Sweet, M.A., Snipes, R.L. and Gaumnitz, E.A. Colonic peptidergic mucosal innervations in constipation predominant irritable bowel syndrome. Gastroenterology 106:A567, 1994.
  22. *Singaram, C., Ashraf, W., Pfeiffer, R.F. and Quigley, E.M.M. Enteric nervous system (ENS) involvement in parkinson’s disease: immunohistochemical evidence of dopamine depletion and lewy body formation in the colon of patients with parkinson’s disease (PD). Gastroenterology 107:4:1237, 1994.
  23. *Singaram, C., Goyal, R.K. and Sengupta, A. Distribution of vasoactive intestinal contractor in the human jejunum and colon.  Gastroenterology 106:A841, 1994.
  24. *Gaumnitz, E.A., Bass, P., Osinski, M., Sweet, M.A. and Singaram, C. Extrinisic cholinergic nerves contribute to elevated lower esophageal sphincter pressures in the chronic acalasia model in the opossum. Gastroenterology 108:4:A604, 1995.
  25. *Gaumnitz, E.A., Bass, P., Sweet, M.A., Gpoodnough, M., Johnson, E. and Singaram, C. Mechanism of botulinum toxin induced 1 ES relaxation in opossum involves cholinergic and peptidergic neurons. Gastroenterology In Press: 1995.
  26. *Sarna, S.K. Singaram, C., Cowles, V.E., Brandon, A., Ryan, R.E. and Gourleay, D. Small intestinal inflammation stimulates abnormal colonic motor activity. Gastroenterology 108:4:A683, 1995.
  27. *Singaram, C., Ashraf, W., Sengupta, A., P{Feiffer, R.F. and Quigley, E.M.M. Specific loss of colonic myenteric dopaminergic neurons in constipated patients with Parkinson’s Disease (PD). Gastroenterology 108:4:A691, 1995.
  28. *Singaram, C., Bass, P., Chignell, K., Coyle, J., O’Brien, R., Dengel, G., Robbins, J., Sweet, M. and Gaumnitz, E. Characterization of the chronically denervated opossum lower esophageal sphincter (IRS). Neurogastroenterology and Motility 7:287, 1995.
  29. *Sweet, M.A., Casper, M.A., Gaumnitz, E.A. and Singaram, C. NADPH-Diaphorase staining intensity in rat jejunum is dependent on the method of fixation. Gastroenterology 108:4:A695, 1995.
  30. Blau, Sigal., Rubinstein, A., Singaram, C., Bass, P. and Cohen, R. Low colonic antioxidant capacity: A possible cause for ulcerative colitis. Pharmaceutical Sciences, 1996.
  31. Siber, M., Singaram, C., Health Care costs and prognosis based on serogenetics in patients with Crohn’s Disease.